4e Guide to the Guides

Below is a comprehensive list to guides for Wizards of the Coast's 4th Edition of Dungeons and Dragons (4e).  This list is primarily drawn from The_Collective's awesome list over at the Wizards of the Coast Forum. This Guide to the Guides has been cut down a bit, reformatted, and restructured for ease of use.

Classes

Ardent
    Ardent Admiration: An Ardent Handbook, Dedekine

Artificer
    Potent Potables - The Artificer Manual, Zathris

Assassin
    All along the Crooked Way: An Assassins Handbook, erleni
    Look Very Carefully: The Shroud Assassins Handbook, erachima

Avenger
    Righteous Wrath: The Avenger's Handbook(Wiki)/(Forum), kilpatds
    Swift & without Mercy: A Guide to Pursuit Avengers, Auspex7

Barbarian
    Appetite for Destruction: The Barbarian's Handbook, lordduskblade

Bard
    Cruel Lullabies: The Bard Handbook, Litigation

Battlemind
    Beyond Bodily Brutality: The Basics of Building Battleminds, Dedekine

Berserker
    Live for the Kill: A Berserker's Handbook, Dragvandil13 *

Blackguard
    Tainted Faith: The Blackguard's Guide, Litigation

Bladesinger
    Masters of Sword and Spell: The Bladesinger's Handbook, AdamClare

Cavalier
    Holy Riders: The Cavalier's Guide, Litigation

Cleric
    Holy Smoke! A Cleric's Handbook Forum, GelatinousOctahedron
    Exemplars of the Faith: A Cleric Build Handbook, GelatinousOctahedron *
    Miniguide to Bow Clerics, GelatinousOctahedron *
    The White Mage - the healic guide, Nausicaa

Druid
    Call of the Wild - A Druid Handbook (including Sentinel Druid) alien270

Executioner
    Death Incarnate: The Executioner's Guide, Litigation *

Fighter
    Harder than a Rock: The Fighter's Handbook, lordduskblade

Hunter
    Harrying Your Prey, the Easy Way: A Hunter's Handbook, thespaceInvader

Invoker
    The Art of the Covenant: A Guide to Invokers, Cazzeo
    The Whole Duty of Man: A Guide to Invokers (Wiki)

Hexblade
    Blades of Cursed Midnight - A Hexblade's Guide, Lord_Ventnor

Knight
    Death Before Dishonor: A Knight's Guide, lordduskblade

Monk
    The Book of Five Traditions: A Monk Handbook, MwaO

Paladin
    Pillars of Faith (and Facestabs): The Paladin's Handbook, Litigation

Psion
    The Mind's Eye: a Psion Handbook, svendj

Ranger
    Thrill of the Hunt: The Ranger's Handbook, lordduskblade

Rogue
    Han Shot First: A Scoundrel's Guide, RenZhe
    Dagger 101: In depth analysis of Rogue damage, the Dagger and general build advice, langeweile *
    The Silent Death - A Handbook to Sniper Rogues, Faytte *

Runepriest
    That Rune Aimer: A Runepriest's Handbook, rayjeeliwan
    Runepriest Wiki & Discussion Thread, MelloRed *

Scout
    Wherever I May Roam: A Scout's Guide, lordduskblade *
    Two Weapons and a Field Guide: The Scout's Handbook, underground player *

Seeker
    To Strive, To Seek, to Find, and Not to Yield: The Seeker's Handbook, WEContact

Sentinel
    Call of the Wild - A Druid Handbook, alien270

Shaman
    Spirited Away: A Shaman Handbook, GelatinousOctahedron

Slayer
    Kill 'Em All: A Slayer's Guide, lordduskblade *

Sorcerer
    The Demiurge Molecule: A Sorcerer's (And Elementalist's) Handbook -DuelistDelSol

Swordmage
    Masters of Blade Magic: A Swordmage Handbook, Herid_Fel

Thief
    What Is Yours Can Be Mine: A Thief's Handbook, tsuyoshikentsu *

Vampire

    Vampire Past the Masquerade, How Not to Suck, MwaO

Warden
    A Rock and A Hard Place: A Warden Handbook, AlphaAnt

Warlock
    Walk With Me in Hell: The Warlock's Guide, DuelistDelSol

Warlord
    The Warlord, Or How to Wield a Barbarian One-Handed, Zelink551
    Optimising Basic Attacks in your Party, Erudo *
    Re-roll Optimisation for your Allies, 11235 *

Warpriest
    Master of My Domain: A Miniguide to Warpriests, GelatinousOctahedron *

Wizard
    Archmage's Ascension: The Wizard's Handbook, RuinsFate

Hybrid and Paragon Multiclass

Striker-Striker

    The Lightning Ranger, SongNSilence *
    Deadly Little Miho - A Godslaying Build, MC-DrowBane *
    Diligence over Dexterity: Introducing the Eladrin Eldritch Executioner, psk20 *

Striker-Leader
    Rune of Vengence (Runepriest|Avenger/Hammer of Vengence) *
    Battery: Circle of Destruction, MC-DrowBane *
    Master of the Radiant Way, Elf Cleric of PelorCentered Breath Monk Radiant Fist, GelatinousOctahedron *

Striker-Defender
    Darth Vader, SwordmageDefenderlock, AlphatheGreat *
    A Safe Haven: Optimizing Sigil Carver to be an Ultimate Defender, billyh *
    The Raging Teleporter: Genasi, BarbarianSwordmage, Ghost Blade, Demigod, GelatinousOctahedron *
    Crimson Legion Champion: Hybrid PaladinWarlock, Questing_Knight, Legendary Sovereign, dkay807 *

Striker-Controller
    Kevin Costner, Prince of Thieves: How i intend to steal the Wand of Orcus, MC-DrowBane *
    Harry Callahan: a Seeker|Ranger Controller, OR How to Play a Hunter with Dailies, WEContact *
    The Distant Cousin - Avenger|Seeker/Son of Mercy, ShakaUVM *

Leader-Leader
    Painless: The Damage Reducer. Dwarf, ClericShaman, Compassionate Healer, Demigod, GelatinousOctahedron *

Leader-Defender
    White Raven Crusader (Paladin/Warlord), Litigation *
    Luke Skywalker (Swordmage/Warlord), Windgate *

Leader-Controller
    Violent Pacifist: Githzerai, ClericWizard, Zealous Demagogue, Archmage, GelatinousOctahedron *
    Mike's Netizard (Wizard/Cleric), mdonais *
    Stunning Thunder-glaive Immo-bola-zer (Wizard/Cleric), Valenkosh *

Defender-Defender
    The Inescapeable Fisherman 2.0, SongNSilence *
    Ioun Grey Stone Marker: Half-Elf Tank 3.0 Catch-22, Mommy_was_an_Orc *
    The Man of Steel: a tough but flexible Defender, BaronSengir *
    Slammin Sammy - A defender build (Ftr|SM), Dielzen *

Defender-Controller
    Sir Marks-a-lot: The Penalty-to-hit Imposition Machine (Fighter pmc Wizard), Valenkosh *
    Swordburst Maximus (ultimate catch-22 build) (Swordmage/Wizard), mellored *

General Hybrid Tips
    Miscibility Table: A Hybrid Handbook, Mommy was an Orc
    Miscibility Table: Hybrid Builds, Mommy was an Orc *

Party Roles

Defender

    Ultimate Defenders, AlphatheGreat
    The Art of Defending, mkill
    4e, Defenders and the MMO mentality, Unmaker *
    Defending can be a Two-Person Job - The "Off-Tank", psk20 *
    Night at the Roxbury: Tricks for Multiple Defender Parties, GelatinousOctahedron

Striker
    The Art of Striking, mkill *
    Axioms of Striker Construction, ophite *

Leader
    Indestructible Parties - Ultimate Leaders, saigon
    The Art of Leading, mkill

Controller
    Controlling 101, alien270

Additional Guides

General Discussion

    A Beginner's Primer to CharOp, RuinsFate *
    The Complete Newbie's Non-Rulebook Glossary, Valenkosh *
    The Handbook of Broken (wiki), [Discussion], kilpatds *

General Optimization
    Modularity: A Guide to CO Tricks and Tactics, AlphatheGreat *
    10 Rules of Party Optimization, Rancid Rogue
    This Party is Off the Hook! A Miniguide to Party Optimization, GelatiousOctahedron
    4e Wealth by Level, Kordak *
    The Art of Optimization, Phryxian_lawnmower *
    MONEY, table(s), awaken_D_M_golem *
    4e Poachable Powers List: A list of good powers to poach from other classes, MwaO
    I've Got That: A Skill Power Guide, MwaO
    Three Step Role Handbook, MwaO

Combat
    List of Bonuses To Saving Throws, mellored *
    The At-Will to Power: A Guide to At-Will enhancing, Dielzen *
    When Everyone is Super: A Miniguide to Classless Damage Boosts, svendj
    Its Elemental - A Guide to Damage Types, Dielzen *
    Back to Basics - A Guide to Basic Attacks, Fardiz *
    Expanded Crit Range - What it's really worth, mellored *
    BAMF: A Guide To Teleportation, Zathris
    And Stay Down: The Polearm Momentum Handbook, Wazat1 *
    Juggling Implements : A simple guide to implement benefits for casters, Kryx *
    Bag of Blades: A Guide to Off-Hand Properties and Free Action Item-Swapping, LazyNinja *
    Neener Neener: The Attack Penalties Handbook, MonkeyGentleman *
    Phalanx tactics and builds, Mellored *
    Archer's Companion, Dzance *

Creatures
    Saddle Up! - A guide to mounts and mounted combat, RuinsFate
    The Pet Store - A Familiar Keeper's Handbook, Krika

Items
    Weapons of Legacy: A Compendium of Magic Items, Armisael
    Holy Symbols for the Non-Divine, mellored
    Let's Accessorize: The Item Guide, Soulliard
    Ginzu Items: A Guide to Dual Purpose Implements & Weapons, GelatinousOctahedron

Nova
    Iaijutsu - A Guide to Alpha-Striking, langeweile *
    The Big Bang: A Guide to Novas, MC-DrowBane *
    Ways to Gain or Downgrade Actions, mellored *
    Using an encounter power more than once per encounter: A Resource Mini-Guide, ChaosMage *

Stealth
    The_Rules_Of_Hidden_Club: Targeting things you can't see in D&D, LordOfWeasels
    Mr Cellophane: How to be unnoticed, mellored

Skills
    Skill Power: a mini-guide to optimizing skill challenges, Ignis_Fatuus *
    Arcana check optimization, SongNSilence *
    Comprehensive Skill Substitution List, Scandranon-sg *

Class-Independent Power Sources
    How I came to be: An adventurer's guide to backgrounds, Kryx *
    Ordered background list, captpike *
    Broken, Beat and Scarred - A Guide to Spellscars, Zathris *
    Variation on Themes: A Theme Handbook, Mommy_was_an_Orc
    This is who I am: A Guide to Themes, Lord Ventnor *
    Who am I Really?: The Theme Handbook, ls612 *
    Window Shopping in the Astral Sea - Deity Optimization Continued, PestilenceX
    Window Shopping in the Astral Sea - A Deity Optimization Guide, GelatinousOctahedron
    The Eternal Seeker's Guide to the Galaxy, Litigation

Build Collections
    DPR King candidates 3.0, borg285 *
    Elysian Fields, Jugulator007 *
    The Hall of Heroes: A Legendary Collective, MC-DrowBane *
    Stage One - A Collection of Build Concepts, Grey Warden *
    The Complete ShakaUVM Collection, ShakaUVM *

Helpful Resources
    D&DI Compendium (WotC)
    4th Edition Update and Errata (WotC)
    D&D FAQs Archive (WotC)
    Issue Archive (Dragon & Dungeon)
    Excerpt Archive (WotC)
    System Reference Document (WotC)